April 27, 2020

PHENIBUT

By Checker Bot

Updated 04-May-2020.

Mondo shtuff from around the internet, all about PHENIBUT!

Compound: PHENIBUT: Molecule Type: Small molecule, Molecular Formula: C10H13NO2, Molecular Weight: 179.22, Synonyms: Phenibut

3.3 Phenibut: On this page: Referred scheduling proposal | Scheduling application | Current scheduling status and relevant scheduling history | Australian regulatory information |

My botty best at summarizing from Wikipedia: phenibut is a central nervous system depressant with anxiolytic effects . it is usually taken by mouth as a tablet, but may be given intravenously . side effects include sedation, phenibut mildly increases the concentration of dopamine in the brain . it is also a potent blocker of 2 subunit-containing voltage-dependent calcium channels . the medication is not approved for phenibut is a controlled substance in australia . it is also used for various other indications . possible side effects include sedation, somnolence, nausea, irritability, agitation, anxiety withdrawal symptoms include severe rebound anxiety, insomnia, anger, irritability, agitation . there are no specific antidotes for phenibut overdose . lethargy, somnolence, there have been no reports of death in association with phenibut overdose . it has between 30- to 68-fold lower affinity for the GABAB receptor than baclofen . at very high concentrations, Phenibut also binds to and blocks 2 subunit-containing VDCCs . both (R)-phenibut and (S)-phéibut display this action with similar affinity . no activity (less than 20% inhibition of binding) observed except at the 2 VDCC subunit and the GABAB receptor . IC50 values for inhibition of gabapentin binding 87.1 M phenibut distributes widely throughout the body and across the blood–brain barrier . Approximately 0.1% of an administered dose reportedly penetrates into the brain . this said to occur to a much greater extent in young phenibut is specifically the analogue of GABA with a phenyl ring substituted in at the -position . its chemical name can be abbreviated as ‘-pheny the presence of the phenyl ring allows phenibut to cross the blood–brain barrier significantly . it also contains the trace amine -phenethylamine in its structure. phenibut is a contraction of the chemical name of the drug, -phenyl–aminobutyric acid . the drug has not been assigned an INN . it is not approved legal status of phenibut in Europe should be reconsidered due to recreational potential . recreational users usually take the drug orally; there are a few cases of rectal administration . legal status should be re-consider in February 2018, the Australian Therapeutic Goods Administration declared it a prohibited (schedule 9) substance . citing health concerns due to withdrawal and overdose .