MESCALINE

Updated 04-May-2020.

Mondo shtuff from around the internet, all about MESCALINE!

The Mescaline experiment: Humphry Osmond and Christopher Mayhew: English: Humphry Osmond was the British psychiatrist who coined the term “psychedelic”. This short video documents an experiment in 1955 in which he administ…

Compound: MESCALINE: Molecule Type: Small molecule, Molecular Formula: C11H17NO3, Molecular Weight: 211.26, Synonyms: 2-(3,4,5-Trimethoxyphenyl)Ethanamine

Mescaline (hallucinogen) Uses, Effects & Hazards – Drugs.com: Mescaline (Peyote) is a hallucinogen and is used as a recreational drug. Includes mescaline side effects, interactions and effects.

THE ABSORPTION, DISTRIBUTION AND URINARY EXCRETION OF MESCALINE IN THE DOG: 1. The plasma levels of mescaline in dog plasma have been determined following intravenous, intramuscular, and oral administration of 20 mgm./kgm. of mescaline sulfate. The decay curves follow the characteristic slope usually related to differences in the route of administration. The intensity of the signs of the pharmacological action of mescaline parallels the plasma levels.

2. Renal elimination of unaltered mescaline in the dog accounts for 28 to 46 per cent of an administered dose, the larger portion of the eliminated fraction being excreted within four and one-half hours and the remainder within twenty-four hours. Only traces of 3,4,5-trimethoxyphenylacetic acid could be detected in the urine.

3. During the first four hours after intravenous administration the concentration of mescaline in the kidney, liver, or spleen is three to six fold higher than in plasma or brain.

My botty best at summarizing from Wikipedia: psychedelic alkaloid known for hallucinogenic effects comparable to those of LSD and psilocybin . it occurs naturally in the peyote cactus, the San Pedro the taste of the cactus is bitter, so contemporary users will often grind it into a powder and pour it in capsules to avoid having to taste it . other mescaline-containing cacti have the usual human dosage is 200–400 milligrams of mescaline sulfate . the average 76 mm (3.0 in) button contains about 25 mg mescaline . dopamine converts into mescaline in biosynthetic pathway involving m-O-methylation . tyrosine and phenylalanine serve as metabolic precursors to synthesis of Phenylalanine serves as a precursor by first being converted to L-tyrosine . numerous approaches utilizing different starting materials have been developed . Hofmann rearrangement of 3,4,5-trimethoxy Cyanohydrin reaction between potassium cyanide and 3,4,5-Trimethoxybenzaldehyde . followed by acetylation and reduction . nitro compound reduction of -nitrotrime Mescaline causes cross-tolerance with other serotonergic psychedelics such as LSD and psilocybin . between 20% and 50% of mescaline is excreted in the subjective effects may include altered thinking processes, altered sense of time and self-awareness . color is distinctive, appearing brilliant and intense . mescaline induces distortions of form and kaleidoscopic experiences . distortions manifest more clearly with eyes closed and under low lighting conditions . like LSD, the drug may cause hallucinogen persisting perception disorder the in vivo function of catecholamines has not been investigated . they may function as antioxidants, as developmental signals, and as cell wall components that resist degradation from pathogens . mescaline acts similarly to other psychedelic agents . it acts as an agonist, binding to and activating the serotonin 5-HT2A receptor with a high affinity . proscaline and mescaline are also both more potent than the drug . the drug was prohibited internationally by the 1971 Convention on Psychotropic Substances . in 1990, the Supreme Court ruled that the state of Oregon many states have legalized peyote usage with “sincere religious intent” dried cactus can be bought and sold legally . mescaline-containing cacti of the genus Echinops special regulations restricting their availability, possession, storage or use may apply . however, anyone may grow and use peyote without restriction, as it is exempt from legislation . in canada mescaline is classified as havelock Ellis was the author of one of the first written reports to the public about an experience with mescaline (1898). Stanisaw Ignacy Witkiewicz described his experience in a 1932 every step you take feels like rubber. but it goes on for hours – like eight hours . a friend smuggled peyote from mexico into the u.s. it appeared in his psychedelic research pioneer Alexander Shulgin says he was first inspired by mescaline experience . Bryan Wynter produced Mars Ascends after trying substance his first time . a study of mescaline and peyote was conducted by UCLA in the 1960s . Disney animator Ward Kimball describes participating in the study . he says he was inspired to write Flow My