LAUDANUM

Updated 05-May-2020.

Mondo shtuff from around the internet, all about LAUDANUM!

Heroine, and after that the laudanum: Review: The King Of Inventors

My botty best at summarizing from Wikipedia: laudanum is a tincture of opium containing approximately 10% powdered opiam by weight (the equivalent of 1% morphine) it was traditionally used as a pain medication and cough suppressant opium tincture’s availability in the u.s. may be in jeopardy . the term laudanum is interchangeable, but in contemporary medical practice the latter is used almost exclusively . paracelsus’ laudanum contained crushed pearls, musk, amber, and other substances . the drug remained largely unknown until the 1660s when a proprietary opium tincture was morphine was mixed with mercury, hashish, cayenne pepper, ether, chloroform, belladonna, whiskey and brandy . laudanum was widely prescribed for ailments from colds to men laudanum was prescribed for relief of menstrual cramps and vague aches . nurses also spoon-fed the drug to infants . the drug was cheaper than a bottle of gin or wine . Laudanum was used in home remedies and prescriptions, as well as a single medication . a 1901 medical book published for home health use gave two “Simple Remedy Formulas” for “dysenter in the US, the food and drug act of 1906 required that certain drugs be accurately labeled . sale of patent medicines containing opiates decreased by 33% after labeling was mandated. the Harrison Narcotics Tax Act of 1914 restricted the manufacture and distribution of opiates . laudanum was supplied to druggists and physicians in regular and concentrated versions . four versions of opium as a Opium, Concentrated (Deodorized and Denarcotized) “Four times the strength of tincture, Used when Tinct. (4) Opium (aqueous), U.S.P., 1890, “Tr. (assayed) Papayer Somniferum” for $2.25 per pint.In 1929–30 “Opium Camphorated, for U.S.P. Tincture: Liquid No. 20 for $2.20 per pint. Concentrated versions were available . “Opium Concentrated, for U.S.P. Tincture: Liquid No. 336”, was “four times the strength of the official tincture” at a cost of $36 per pint opium was no longer a medically accepted “cure-all” in the 20th century . laudanum became obsolete as an analgesic, since its principal ingredient is morphine . codeine in 1970, the US adopted the Uniform Controlled Substances Act, which regulated opium tincture (Laudanum) as a Schedule II substance . by the late 20th century, lauda there is probably no single reference that lists all the pharmaceutical variations of laudanum . pharmacists and drug manufacturers were free to alter such formulas . the alcohol content of Laudanum probably varied substantially . four variations of laudanum listed here were used in the u.s. during the late 19th century . the first, from an 1870 publication, is “Best Turkey opium 1 oz., slice opium, 2 ounces; saffron, 1 ounce; bruised cinnamon and bruised cloves, each 1 drachm; sherry wine, 1 pint. Mix and macerate seven drops of this preparation contain about 1 grain of opium . attributed to the united states pharmacoepia of 1863 . opium tincture is regulated as a Schedule II drug under the Controlled Substances Act . each mL contains 10 mg of anhydrous morphine (the equivalent of 100 mg of powdered Tincture of Opium is one of many “unapproved drugs” regulated by the FDA . opium tincture was sold prior to the Federal Food, Drug & Cosmetic Act of 1938 . the FDA closely monitor at least one manufacturer still produces opium tincture in the UK as of 2011 . “Gee’s Linctus” is also available from most UK pharmacies, especially independent stores . it is a pharmacological effects of opium tincture are due principally to its morphine content . most modern formulations do not contain the alkaloid narcotine . even modest doses of n “de-narcotized” or “deodorized” opium tincture removes the narcotine . peak plasma concentrations of the morphine content are reached in about one hour . the opium tincture is gradually tapered over a 3- to 5-week period . the amount of codeine is negligible and does not have any appreciable analgesic effect . the usual starting dose in adults is 1.5 mL by mouth every 3 to 4 hours . this is the equivalent of 15 mg—approximately 14 grain—of morphine per dose . for the opioid opium tincture contains 17–19% alcohol, by volume . doses should be carefully measured using an oral syringe or calibrated dropper . Apothecary measurements should be avoided in contemporary in contemporary medicine, there are 20 drops per mL . care and caution should be taken in administering doses of both drugs . the dosages in this article refer to Apothecaries weight and fluid measure . apothecaries’ fluid measures typically list 60 minims per fluid dram . accidents or deliberate overdose is common with opium tincture . overdose and death may occur with a single oral dose of laudanum was not uncommon in the mid-19th century . opium tincture’s weaker cousin, paregoric, contains only 0.4 mg of morphine per mL . the term “camphorated tincture of opium” is avoided in place of paregoric . to avoid potentially fatal outcome, the term is avoided since the former can easily be mistaken . the confusion persists, diluted tincture of opium is prescribed to treat withdrawal symptoms in newborns . infants have received 25-fold overdose of morphine, sometimes resulting in fatalities . pharmacists have misinterpreted ” long-term use of laudanum in nonterminal diseases is discouraged due to the possibility of drug tolerance and addiction . if overdose of opium tincture is suspected, rapid professional intervention is required . the primary concern is re-establishing a viable airway and institution of assisted or controlled ventilation if the patient is unable to breathe on his own . other supportive measures such as the use of vasopressors and Laudanum appears in Charles Baudelaire’s “The Double Room,” published in 1869 . laudanum is portrayed as the surgical drug of choice for 15th-century physicians in Lawrence Schoonover’s novel laudanum-addicted character also appeared in Wilkie Collins’ novel Armadale (1864–66) in Mary Shelley’s novel Frankenstein (1818), Victor Frankenstein takes the drug as his only means in Sara Collins’ novel “The Confessions of Frannie Langton” (2019) the titular character becomes addicted to laudanum . in Dan Simmons’ novel “Drood” (2009) the nar