GRANULOMA

Updated 05-May-2020.

Mondo shtuff from around the internet, all about GRANULOMA!

Granulomatous Lung Disease: An Approach to the Differential Diagnosis: Article Citation: Sanjay Mukhopadhyay and Anthony A. Gal (2010) Granulomatous Lung Disease: An Approach to the Differential Diagnosis. Archives of Pathology & Laboratory Medicine: May 2010, Vol. 134, No. 5, pp. 667-690.

My botty best at summarizing from Wikipedia: a granuloma is a structure formed during inflammation that is found in many diseases . a small nodule can represent anything from a harmless nevus to a malignant tumor . the term radiologists often use the term granuloma when they see a calcified nodule on x-ray or CT scan of the chest . the most accurate use of the term requires a pathologist to histiocytes fuse to form multinucleated giant cells (Langhans giant cell) macrophages in granulomas often referred to as “epithelioid” term refers they have larger nuclei than ordinary macrophages and their cytoplasm is typically more pink when stained with eosin . these changes are thought to be a consequence of “activation” of the macrophag all granulomas contain additional cells and matrix . lymphocytes, neutrophils, eosinophils and multinucleated giant cells also present . the additional cells are sometimes a clue to granulomas are seen in a wide variety of diseases, both infectious and non-infectious . necrosis refers to dead cells that appear as a mass of formless debris . “caseation” refers to a form of necrosis that appears cheese-like (“caseous”) granulomas of tuberculosis tend to have infectious causes . multinucleated giant cells Histoplasma organisms can be demonstrated within the granulomas by biopsy or microbiological cultures . granularomas in leprosy are found in lymph nodes draining the site of the scratch granulomas are characteristically “suppurative”, i.e., pus forming, containing large numbers of neutrophils . it is believed to be caused by antibody cross-reactivity . other in most cases of sarcoidosis, the granulomas do not contain necrosis . in the lungs, scarring can cause a condition known as pulmonary fibrosis that impairs in the heart, it can lead to rhythm disturbances, heart failure, and even death . granulomas are often found and are a clue to the diagnosis . patients typically aspirate food because they have e food particles in lung biopsies is diagnostic, but it is not a true granuloma . Typically there is a central zone of necrobiotic generation of collagen . mucin de granulomatosis with polyangiitis (GPA) and eosinophilic vasculitis . necrosis is a disease that affects children, usually of african descent . granulomatous means characterized by granulateomas or granularomata . plural means granulationomatous .